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Like energy balance is harder to manage, hormones are hard to manage, sleep is difficult

Activation of immune system in colonic mucosa followed by infiltration of numerous immune cells and release of inflammatory cytokines are observed in IBS patients as compared to healthy subjects (Martin-Vias and Quigley, 2016

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However, free-living animals harbored a larger number of strains than captive ones and the potential patho-physiological consequences for infected animals needs further consideration