Current evidence indicates that curcumin exerts protective effects against epileptic seizures and associated memory impairment, potentially through modulation of brain monoamine levels (Forouzanfar et al., 2021)
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Secondly, in the liver and kidney, betaine serves as a methyl group donor in betaine-homocysteine methyltransferase (BHMT, a zinc metalloenzyme) reaction in which betaine transfers its methyl group to homocysteine forming methionine (Millian and Garrow, 1998