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Beyond bile acids, the classical pathway involves the translocation of Lipopolysaccharides (LPS) from Gram-negative bacteria across a compromised intestinal barrier

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Besides, dual GLP-1/GIP receptor agonists (DA-JC4, DA5-CH, DA-JC1 and DA-CH3) reduced inflammation response, amyloid plaques and tau phosphorylation in brain, reversed memory loss, and enhanced synaptic plasticity in hippocampus of APP/PS1 mice (186, 234, 236, 238)