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NTS receives vagal input from the gastrointestinal tract and gustatory input from the tongue (Grill and Kaplan, Figure 1 GLP-1R-driven activation of the mesolimbic neurons On the basis of immediate early gene expression analysis it seems that GLP-1 or its analogs can increase neuronal activity in the mesolimbic system

However, since the GLP-1 receptor is expressed in many tissues beyond its primary target (e.g., the brain, heart, and lungs), current research aims to investigate the comprehensive systemic effects of these drugs, particularly on cancer

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