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Upon administration, it affects the areas of the brain that control appetite and food intake, leading to a decrease in hunger sensations and an increased feeling of fullness

Diabetologia (2011) 54:137987

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B6 mice fed with a normal fat diet (Normal Diet) or HFD (DIO) received the following treatment regimens: saline (Saline), scExe4 donor DNA-loaded LNP (Donor), or scExe4 donor DNA plus Cas9-coding DNA-loaded LNP (Donor+Cas9)