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Collectively, the complex interactions between HIF-1 and its diverse hypoxia-dependent and non-hypoxia-stimulated regulatory pathways form a specific, multifaceted hypoxia-responsive pathway that is critical for cellular adaptation to changing environments and for orchestrating inflammatory responses

In addition, under HFD conditions, most SREBP-1c downstream genes contributing to hepatic lipid accumulation were downregulated (Figure 3B)

[DOI] [PMC free article] [PubMed] [Google Scholar] 53.Cao L., Zhang D., Chen J., et al