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Exclusion of trials with 60 years: HR = 0.75 (95% CI: 0.600.92)

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The nested casecontrol study design was chosen because it (1) enhances statistical efficiency (i.e., no need to classify treatment exposure for each person-moment of follow-up), (2) allows homogenous populations to be utilized, reducing the potential selection bias in conventional casecontrol study design, (3) minimize the concern of immortal time bias under a variety of cohort study designs [22,23,24], (4) accommodates rare events (i.e., incident NAFLD/NASH events according to previous UK and US studies), and (5) allows treatment doseresponse analysis [25, 26]