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Compared to other established diabetes medications: Metformin Mounjaro offers greater HbA1c reduction (2.0% vs 1.0-1.5%) and promotes weight loss rather than weight neutrality, but costs significantly more and requires injection rather than oral administration SGLT2 inhibitors (e.g., empagliflozin, dapagliflozin) SGLT2 inhibitors have established cardiovascular and renal benefits from outcome trials

They also indicate that rates of gout were about 12% higher among those taking GLP-1 drugs as well