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As the global population continues to age, the incidence and disability rate of OA steadily rise, creating significant economic and caregiving burdens on society and families

Alternatively, extracellular NAD + can be utilized by NAD + glycohydrolases, generating NAM, NR, or NMN outside of the cells, which can then be transported intracellularly for NAD + synthesis 65,66

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GSH not only acts as an antioxidant to minimize oxidative stress but is also profoundly related to cisplatin and carboplatin chemoresistance through reducing drug uptake and increasing drug inactivation in ovarian cancer (64)