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When the amount of sugar in your bloodstream spikes, your pancreas responds by releasing insulin, which tells your cells to start taking in glucose from the blood

HbA1c measures the average blood sugar levels over the past three months, corresponding to the average lifespan of red blood cells (RBCs) and indicating the extent to which the RBCs are "sugar-coated." For reference, the American Diabetes Association (ADA) advises that the target A1C for most adults with diabetes should be below 7%

doi: 10.1126/sciimmunol.abg3551 133 KimJDeBerardinisRJ

In particular, improving first-submission approval by even 10 percentage points (say, via better PA documentation) can have large downstream impact on prescription volume