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In this vein, it has been reported that rates of urea excretion and glutamine formation are generally decreased in obesity, being activated alternative mechanisms for excess nitrogen disposal, such as the synthesis of nitric oxide from arginine [40]

While single peptides work well, strategic combinations often produce superior results by targeting multiple biological pathways

MC1R is a G-protein-coupled receptor (GPCR) that, upon agonist engagement, activates the Gs/adenylate cyclase pathway, increasing intracellular cAMP and activating PKA-linked signalling cascades that upregulate tyrosinase activity and drive eumelanin synthesis the dark, UV-protective form of melanin

[DOI] [PMC free article] [PubMed] [Google Scholar] 112.Xiong H, et al