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Notably, treatments with Nivolumab or Pembrolizumab, which inhibit the PD-1 protein on T cells and enhance the immune response, have been associated with the development of autoimmune diabetes in approximately 60% of cases [75]

To further investigate tumor angiogenesis markers for breast cancer for evaluation of anti-angiogenic therapy efficacy, promoting vascular normalization may be a necessary prerequisite for reversing drug resistance