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(Regulatory Toxicology and Pharmacology, 2020) reported a preclinical safety package designed to support potential drug development

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Figure 2 In the SMFA assay, using blood with gametocytes pre-exposed to MB for six hours (SMFA assay), the infection rate and intensity were extremely reduced ( Figures 2D, E ), thus showing high inhibition in all tested concentrations (5 M 82.7%, 10 M 94.8%, and 20 M 100.0%) with a total blocking of transmission at the highest concentration