In Phase 2 trials, retatrutide was administered as a once-weekly subcutaneous injection using a structured dose escalation from 2 mg up to 12 mg over 12 weeks
The focus is usually on appetite loss, nausea, or constipation
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Use of recombinant human growth hormone to increase growth in short-statured children with constitutional growth delay has been challenged for its modest efficacy in increasing ultimate height, high cost, limited evidence for psychosocial benefit, and some unresolved concerns about long-term posttreatment safety
