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[5] Glutathione depletion has been linked to a number of disease states and groups, including: Athletic overtraining Major injuries and trauma Patients with wasting diseases such as HIV and AIDS Lung cancer Gut-based diseases such as Crohns and ulcerative colitis Chronic fatigue syndrome Alcoholism and fatty liver disease Diabetes and low glucose tolerance Cancer [6] Glutathione and autoimmune disease An autoimmune disorder occurs when a persons immune system mistakenly attacks their own body