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The hepatocyte cytochrome P450 enzyme system represents the principal metabolic machinery, participating in oxidation, reduction, hydrolysis, and conjugation reactions of various exogenous and endogenous substances ( SCFAs undergo distinct metabolic fates upon entering the liver

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Treatment of neonatal Lep ob/ob mice with leptin restored AgRP inputs onto PVH preautonomic neurons, yet leptin treatment did not restore AgRP inputs onto neuroendocrine components of the PVH (Bouyer and Simerly, 2013)