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Discuss treatment with a provider if you have bleeding disorders, take blood thinning medications, are immunosuppressed, prone to cold sores, or are pregnant, breastfeeding, or under 21 (use not recommended)

[Google Scholar] 28.Maarbjerg SJ, Borregaard J, Breitschaft A, Donsmark M, Sndergaard FL

In guidance published on 5 June 2025, the MHRA said that GLP-1 RAs which include semaglutide, liraglutide and tirzepatide should not be taken during pregnancy, just before trying to get pregnant or while breastfeeding

Bertilimumab, a monoclonal antibody against eotaxin-1, has been tested in a Phase 2 trial in ulcerative colitis (81)