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Discussion High Pyroglutamic acid indicates a disturbed GSH homeostasis in symptomatic TTR-V30M gene carriers In a recent study, we demonstrated that the formation of the aggregation-prone NNTTR species, initially discovered in plasma from TTR-V30M gene carriers [21], is promoted by the formation of a disulfide bridge [22]

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Potential doses of vitamin E can be used in the range of 200400 mg/day, for limited period of time, possibly in combination with other antioxidants, and under medical supervision

Neither Ozempic nor Rybelsus has FDA approval for this use