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SPRR2e measurement in TR146 cells In vitro experiments were carried out using the TR146 human buccal epithelial squamous cell carcinoma cell line (94), obtained from the European Collection of Authenticated Cell Cultures and cultured in Dulbeccos Modified Eagles Medium (DMEM, Sigma-Aldrich), supplemented with 10% fetal bovine serum (FBS) and 1% penicillin-streptomycin

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