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The heat causes your blood vessels to dilate , a process known as vasodilation, improving circulation to your skin and extremities, and prompting your sweat glands into action to cool the body through evaporation

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[25] During times of low cellular stress, a complex forms through direct proteinprotein interactions between GSTP and the C -terminus of JNK, effectively preventing the action of JNK and thus its induction of the JNK pathway

It's not a diagnosis in itself but rather a symptom of an underlying problem