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The tablet must be taken on an empty stomach with limited water and no food or other medications for 30 minutes

This combined approach revitalizes cytotoxic T cells, enhancing their ability to mount an effective antitumor response and promoting tumor regression ( The ClinicalTrials.gov database (revised February 2025) (113, 114) highlights that, although numerous studies examine the impact of cholesterol-lowering drugs on cancer, only a limited number of clinical trials focus specifically on their effects on the tumor immune microenvironment

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In addition, knockdown of mitochondrial NADH-generating citric acid cycle enzyme MDH2 in mice extended lifespan (Mao et al., 2025), which may have been due to an oxidizing shift in both the mitochondrial and cytoplasmic [NAD + ]/[NADH], although the potential mechanism driving the oxidation of the cytoplasmic [NAD + ]/[NADH] is unclear