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The structure of MET protein comprises a highly glycosylated 45-kDa extracellular -subunit and a 145-kDa transmembrane -subunit, which are linked together by a disulfide bridge (Fig

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65 ) (Addgene, 52961) for CRISPRCas9 KO or into pLV hU6-sgRNA hUbC-dCas9-KRAB-T2a-Puro 66 (Addgene, 71236) for CRISPRi knockdown, as previously described 41

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