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To tackle these global health issues that predominantly track from childhood to old age (49, 50), it is crucial to address the pressing concerns identified by health organizations and experts worldwide (51, 52)

The transcriptional activity of NRF2 is regulated post-translationally by Kelch-like ECH-associated protein 1 (KEAP1) which mediates the degradation of NRF2

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Nevertheless, the direct effect of ZMTP nanosheet on the physiological activities of mBMSCs were first investigated by incubating mBMSCs directly with ZMTP or single MnTCPP + or Zn 2+ , and the CCK-8 results showed insignificant changes of the viability of mBMSCs even in 96 h of treatments in different groups (Fig