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Johnson PM, Kenny PJ

The authors administered oral Dihexa to APP/PS1 transgenic mice (a standard amyloidopathy model of Alzheimers disease) and showed that brain AngIV levels were elevated relative to wild-type after Dihexa administration, that spatial learning and memory were restored on Morris water maze testing, that hippocampal neuronal density and synaptophysin protein expression were preserved, that astrocyte and microglial activation were reduced, and that pro-inflammatory cytokines (IL-1, TNF-) decreased while anti-inflammatory IL-10 increased

41% of global BMI-related deaths and 34% of global BMI-related DALYs occur due to CVD in people with obesity [5]

Were discussing it because its the most promising compound in the pipeline and patients are asking about it constantly