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For example, a doctor might prescribe both a biguanide and a sulfonylurea

In addition, A1R signaling inhibits excitatory synaptic transmission through the inhibition of glutamate release, ionotropic glutamate receptors, and neuronal excitability via inward rectifying, cAMP/PKA/DARPP-32 pathway, as well as calcium-activated potassium channels (61, 62)

Following this pattern, TMEV-infected SJL/J mice treated orally with this same antibiotic mixture showed protection against motor dysfunction, axonal damage, and CNS immune infiltration, likely through enhanced CD4 + CD39 + T cells, CD5 + CD1d + B cells, and downregulated IL-17 in the periphery (Mestre et al., 2019)

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