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More doses of L-DOPA combined with decarboxylase inhibitors have to be repeated under this scenario, thus denoting a complicated interaction of PD medications with GI tract-related symptoms

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Limitations and Considerations BMI cutoff used is in between the typical cutoffs for overweight and obese Limited generalizability given that the majority of patients included were Caucasian, with only 12.5% African American male predominant population studied, with only 27.7% females It remains to be demonstrated if treatment with semaglutide has a cardioprotective and preventative benefit in patients who do not have pre-existing cardiovascular disease PowellWiley TM, Poirier P, Burke LE, et al

Patients should be encouraged that whilst some initial adjustment period may occur with any new medication, most individuals who continue treatment find that their sleep quality stabilises over time