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Through -KG-dependent dioxygenase, the amino acid metabolite -KG is also involved in regulating histone and DNA demethylation (Xu et al., 2011

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Whilst we found that ex vivo vehicle treated cells produced high levels of cytokines, including IL-5, IL-13, IL-9 ( Supplementary Figures 4BD ), and modest amounts of IL-10 and IL-6 ( Supplementary Figures 4E, F ), melatonin treatment greatly reduced the concentration of all cytokines analyzed ( Supplementary Figures 4B F )