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It is well-established that early-life fructose exposure increases anxiety- and depressive-like behaviors in rodents [8], and we recently showed that maternal GLU or FRU diets similarly induce hyperactivity, anxiety-like, and depressive-like behaviors in offspring [10]

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Despite the obstacles, some small molecules mentioned in this review have already applied clinically, whose application in HTx can be quickly translated due to its confirmative safety and efficiency in human (Table 3)