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Medical Professional Society Guidance (ACOG, SMFM, NMA) U.S

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do not use if cloudy, discolored, or containing particles For Ozempic Multi-dose Pen: Attach a new, unused pen needle securely to the pen (typically 4mm) For a new pen only: Perform a flow check (priming) by dialing to the flow check symbol and pressing the dose button until a drop appears Dial your prescribed dose For Wegovy Single-dose Autoinjector: Remove the cap just before use No priming is needed as this is a prefilled, single-use device with built-in needle Site Selection and Preparation (Both Products): Choose an injection site with adequate subcutaneous tissue: abdomen (preferred, at least 2 inches from navel), front of thigh, or upper arm Rotate injection sites weekly to prevent lipodystrophy (abnormal fat distribution) Clean the selected site with an alcohol swab and allow to air dry completely (approximately 10 seconds) Avoid areas with bruises, scars, or lipodystrophy Injection Technique: For Ozempic: If needed (particularly for lean individuals), gently pinch the skin to create a fold of subcutaneous tissue Hold the pen at a 90-degree angle to the skin surface Insert the needle completely with a quick, firm motion Press and hold the dose button until the dose counter shows "0" Continue holding the button and keep the needle in place for at least 6 seconds to ensure complete dose delivery Release the dose button, then withdraw the needle straight out For Wegovy: Place the autoinjector firmly against the skin at a 90-degree angle Press and hold the autoinjector firmly against the skin You will hear a click when the injection starts Hold until you hear a second click and/or the yellow bar stops moving (typically takes about 5-10 seconds) Remove the autoinjector from the skin Post-Injection (Both Products): Do not rub the injection site For Ozempic: Safely dispose of the used needle in an FDA-cleared sharps container and replace the pen cap For Wegovy: Dispose of the entire used autoinjector in an FDA-cleared sharps container Document the injection site and date to maintain proper rotation Store according to product-specific instructions (Ozempic can be stored at room temperature for up to 56 days after first use

Absolute muscle mass dropped only 5-10%, but fat mass plummeted 41-73%. Meanwhile, human trials showed that over 12 weeks, fat made up 70% of weight loss, with lean mass coming in at 30%