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The TIN2 TBM binding site in TRF1 TRFH overlaps with that of other telomere-binding factors (e.g., PinX1 and TERB1

However, many endogenous and exogenous factors such as free radicals produced by chronic inflammation in the body, certain metabolites of cells and gut microbiota [14], as well as chemical carcinogens in the environment [15], ultraviolet (UV) radiation attack intracellular DNA and may cause a variety of DNA damage [3]

By blocking NNMT, you're keeping visceral fat cells in a more reactive state even as overall caloric restriction continues