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N Engl J Med 326:22, 1992 The effect of impaired glucagon suppression on plasma glycemia is dependent on insulin Glucagon Glucagon Insulin Non-diabetic Diabetic HGP Glucose Glucose HGP Non-diabetic Diabetic AJP 277:E283;1999 Placebo Exenatide 0.10 g/kg sc 0 60 120 180 Time (min) Exenatide or placebo Exenatide Reduces Postprandial Glucagon Secretion in Patients With Type 2 Diabetes Meal 200 150 Plasma Glucagon (ng/L) 100 50 0 N = 20.Mean (SE)

The reduced mitochondrial activity and metabolic alterations observed in this study could be explained by thiol-dependent ROS signaling mechanisms similar to those seen in tumor cells 37

GLP-1 targets areas of the brain that regulate appetite and blood sugar

Therefore, the theoretical increased cellular delivery & efficacy of liposomal vitamin C is estimated to be over 200 times more than for oral ingestion of regular vitamin C