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A narrative review of glutathione supplementation reported that 37.5 percent of participants receiving 1.2 g of glutathione twice weekly for six weeks experienced temporary lightening, yet benefits faded within six months, and 32 percent experienced adverse events such as liver dysfunction or anaphylaxis

Most studies have used in vitro exposure to a single, relatively high dose of environmental toxins, which is very different from the actual exposure of humans to the environment, which is usually a mixture of multiple pollutants in chronic low doses