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Moreover, preclinical studies revealed that ferroptosis inducers contribute to the enhanced efficacy of immunotherapy [125] and chemotherapy [126]

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Individuals with a single ApoE 4 allele have more than a three times higher risk of developing AD, whereas in people who have two ApoE 4 alleles, the risk of developing AD is increased by eight- to tenfold compared with carriers of ApoE 3 [32, 57]

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