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However, access challenges related to cost and insurance coverage may limit equitable distribution of these therapies ^19
The removal of this region and the multivalent presentation on a ferritin nanoparticle significantly improved DCFHPs neutralizing potency in mice relative to the use of unedited spike, since it allows the immune system to not get distracted by creating an antibody response against a region that is ultimately nonneutralizing [134]
Furthermore, most of the variation in the microbiome between healthy individuals is unexplained 38 , even within single-country cohorts 33,42 , further confounding the definition of a health-associated gut microbiome
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