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Depending on those results, the company will seek FDA approval, the spokesperson said

Contact your GP or prescriber if you experience: Severe or persistent diarrhoea lasting more than a week Signs of dehydration: dizziness, dark urine, extreme thirst Blood in your stool or black, tarry stools Severe abdominal pain that doesnt improve Significant worsening of your IBS symptoms that affects daily life Inability to keep fluids down for more than 24 hours Your prescriber may recommend adjusting your dose, extending the time between dose increases, or trying different ways to manage symptoms

Dermatol 156, 9971004