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Adipose tissue, particularly visceral fat, produces inflammatory cytokines that create systemic inflammation affecting every organ system

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By combining GLP-1, GIP, and glucagon receptor activity, these therapies may enhance appetite suppression, improve insulin sensitivity, and increase energy expenditure

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Weight regain wasnt the only thing that happened after stopping GLP-1s

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This additional mechanism may explain why many patients experience faster and more significant weight loss with Tirzepatide versus Semaglutide

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