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Each reshaped medicine, but also brought unintended consequences: overprescribing, affordability crises, and backlash when the costs or risks became undeniable

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* Correspondence: Gen Ohtsuki, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers