retatrutide better than semaglutide vs. Ozempic: The Triple Agonist That May Change Everything., hits one receptor. Retatrutide hits Semaglutide vs Tirzepatide vs Retatrutide:

Gallbladder-related events, including cholelithiasis (gallstones) and cholecystitis, were reported in a small number of participants receiving active treatment a finding consistent with the known class effect of GLP-1 receptor agonists

Issues impacting the GI system are the most common for weight loss medications

Journal of Endocrinology 221.1 (2014): T1-T16

When treated with insulin lowering methods, including SGLT-2 inhibitor and the ketogenic diet, the tumor cells had a better response to PI3K inhibitors ( Conclusion Over a long period, insulin has been regarded as a compensatory hormone of IGF-1 in cancer development and progression