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This triple-action mechanism distinguishes it from existing approved therapies such as semaglutide (GLP-1 receptor agonist only) or tirzepatide (GLP-1/GIP dual agonist)

Box 6.1 Simple rules in diarrhoea Patients often consider themselves constipated if their bowels are not open on most days, though normal stool frequency is very variable, from 3 times daily to 3 times a week

[1] Certain patients should generally avoid NSAIDs, including those with advanced kidney disease, prior complicated ulcers or upper GI bleeding, decompensated heart failure, cirrhosis, or third-trimester pregnancy

Alcoholic liver disease: new insights in pathogenesis lead to new treatments