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This variability may be attributed to the release of miR-122 from healthy liver cells, which can have physiological effects on distant tissues [71]

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This makes oxidative stress more severe and widespread

Curr Biol 19:492497 Tonkin ET, Wang TJ, Lisgo S, Bamshad MJ, Strachan T (2004) NIPBL, encoding a homolog of fungal Scc2-type sister chromatid cohesion proteins and fly Nipped-B, is mutated in Cornelia de Lange syndrome