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Recently, in an experimental model of Fibromyalgia, characterized by systemic inflammation with overexpression of NF-kB and high levels of IL-1 and TNF in the hippocampus, it was documented that physical activity reduces hippocampal inflammation and activates PGC-1/FNDC5/BDNF lineage genes with positive effects on neurogenesis [144]

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(PubMed) Xu S, Huang H, Qian J, et al