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As a classical inducer of ferroptosis, erastin can inhibit the transcriptional activity of AR and its splice variants in vitro and in vivo

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The interaction of ECM1 with LRP1 was verified using proximity ligation assay (PLA) (Fig

To further investigate whether lysosomal LPO is responsible for ferroptosis induction, we synthesized a lysosome-targeting probe based on NBD-Pen with morpholine (a lysosomal targeting group) 16 , named 2,2,6-trimethyl-4-(2-morpholinoethyl)(7-nitrobenzo[ c ][1,2,5]oxadiazol-4-yl)amino-6-pentylpiperidine-1-oxyl (Lyso-NBD-Pen) (more polar diastereomer 1, less polar diastereomer 2) (Supplementary Fig