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Rapid weight loss with GLP-1 medications can deflate deep and superficial facial fat compartments, exposing laxity and altering contours

, which involved healthy test subjects aged 21-61 and followed a randomized, placebo-controlled, double-blind, ascending dose design [16]

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The glucagon peptide family [glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic peptide (GIP) and glucagon] Figure 2: Simplified schematic overview of the glucagon superfamily of peptides [28] The glucagon peptide family members [GLP-1, GIP and glucagon] have similar peptide sequences, permitting the development of single-sequence multi-receptor agonists [4]