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A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)

The onset of metformin-associated lactic acidosis is often subtle, accompanied only by nonspecific symptoms such as malaise, myalgias, respiratory distress, somnolence, and abdominal pain

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At t = 0 min, a glucose solution (45 g glucose dissolved in water to a total volume of 180 ml) was infused into the duodenum over 60 min (i.e