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Enhanced resistance to viruses in nicotiana edwardsonii ColumbiaIs dependent on salicylic acid, correlates with high glutathione levels, and extends to plant-pathogenic bacteria and abiotic stress

Relevant in vivo and in vitro experiments have confirmed that IGFBP-L1 methylation exerts a pro-oncogenic effect by promoting PI3K/AKT phosphorylation and IGFBP-L1 methylation has become a potential marker for the early detection of esophageal cancer, as well as a predictive marker for PI3K-targeted therapy in esophageal cancer (85)