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Clinical trials including STEP 14 and SURMOUNT 14 demonstrated GLP-1 efficacy but also showed dose-dependent side effects requiring titration under medical supervision

Loomba R serves as a consultant to Aardvark Therapeutics, Altimmune, Anylam/Regeneron, Amgen, Arrowhead Pharmaceuticals, AstraZeneca, Bristol-Myers Squibb, CohBar, Eli Lilly, Galmed, Gilead, Glympse Bio, Hightide, Inipharma, Intercept, Inventiva, Ionis, Janssen Inc., Madrigal, Metacrine Inc., NGM Biopharmaceuticals, Novartis, Novo Nordisk, Merck, Pfizer, Sagimet, Theratechnologies, 89 Bio, Terns Pharmaceuticals, and Viking Therapeutics

Beyond the simple numbers, excessive caloric intake and fat accumulation create physiological conditions that work against muscle building

Large-scale, long-term clinical trials are still lacking to decisively prove anti-aging benefits or prevention of cognitive decline