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doi: 10.1038/ni.3796 18 KnottSRVWagenblastEKhanSKimSYSotoMWagnerMet al

One preclinical study (Valdecantos et al., ADA 2024) showed combination benefit in obese rats

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GSH is essential for immunomodulation of both innate and adaptive immune system functions, including T-lymphocyte proliferation, polymorphonuclear neutrophil phagocytosis, and dendritic cell functions, and is also important for fine-tuning the innate immune response to infection and for the first step of adaptive immunity involving antigen-presenting cell (macrophages, dendritic cells)-related antigen presentation (Morris et al., 2013