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We typically recommend a 24 week break after 812 weeks on for chronic protocols the necessity isn't fully established, but it's a sensible conservative approach for long-term use

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This is illustrated in Figure 10B, showing a 50% reduction in rate of glutamate uptake in the glutamatergic cerebellar granule neurons between the ages of 4 and 8 days in culture (Peng, 1995)

N Jelovac, P Sikiric, R Rucman, M Petek, D Perovic, A Marovic, T Anic, S Seiwerth, S Mise, B Pigac, B Duplancie, B Turkovic, G Dodig, I Prkacin, D Stancic-Rokotov, I Zoricic, G Aralica, B Sebecic, T Ziger, Z Slobodnjak, The effect of a novel pentadecapeptide BPC 157 on development of tolerance and physical dependence following repeated administration of diazepam