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The use of GLP1-RAs represents a potential risk for gallbladder or biliary tract diseases because GLP-1RAs may inhibit gallbladder motility and delay gallbladder emptying by suppressing secretion of cholecystokinin leading to sludging and stone formation

These neurons either express the neurotransmitter norepinephrine (NE) or the neuropeptide CCK and are monosynaptically connected to calcitonin generegulated peptide (CGRP)-expressing neurons in the lateral parabrachial nucleus (lPBN) of the pons [61], which are in turn monosynaptically connected to protein kinase C (PKC)-delta-expressing neurons in the central nucleus of the amygdala (CeA) in the forebrain [62, 63], thus forming a tripartite functional unit

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