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Interest accelerated after Russian aging researchers proposed that Epitalon might influence cellular aging pathways through effects on telomerase activity, pineal gland signaling, oxidative stress, and circadian regulation

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The synbiotic comprising two pills, each containing 4 10 9 CFU of Lactobacillus acidophilus CBT LA1, 4 10 9 of Lactobacillus casei CBT LC5, and 8 10 9 of Bifidobacterium lactis CBT BL3 together with 1.6 g of inulin was administered to non-dialyzed CKD patients in a 12-week randomized, double-blind, placebo-controlled study

We emphasized that the approach to stratification by age and mental health diagnosis, as well as volume standardization of the measure performance scores, is sufficient to account for differences between hospitals without further need for additional stratification